Doniphan is located alongside U.S. Highway 281 in Hall County, in the south-central part of Nebraska and just four miles south of Interstate 80. While the typography is generally flat, visitors and newcomers to the area often comment on the spectacular sunsets and natural beauty of the Platte River, which is located just two miles away.

Highway miles to major cities:

Lincoln, Nebraska 95

Omaha, Nebraska 147

Chicago, Illinois 612

Dallas, Texas 633

Denver, Colorado 402

Kansas City, Missouri 286

Minneapolis, Minnesota 523